BDBM50484223 CHEMBL1822241

SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(Br)c3c2)c1F

InChI Key InChIKey=HLDIRQFSCNLEAS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50484223   

TargetSerine/threonine-protein kinase B-raf(Human)
Arraybiopharma

Curated by ChEMBL
LigandPNGBDBM50484223(CHEMBL1822241)
Affinity DataIC50: 4nMAssay Description:Inhibition of full length B-Raf V600E mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Arraybiopharma

Curated by ChEMBL
LigandPNGBDBM50484223(CHEMBL1822241)
Affinity DataIC50: 4nMAssay Description:Inhibition of full length human B-Raf V600E mutant expressed in baculovirus infected insect cells assessed as [gamma-33P]incorporation into MEK after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Arraybiopharma

Curated by ChEMBL
LigandPNGBDBM50484223(CHEMBL1822241)
Affinity DataIC50: 44nMAssay Description:Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human MALME-3M cells after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Arraybiopharma

Curated by ChEMBL
LigandPNGBDBM50484223(CHEMBL1822241)
Affinity DataIC50: 260nMAssay Description:Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human A375 cells after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed