BDBM50484476 CHEMBL1916325

SMILES NC(=O)[C@@H](CCC(F)(F)F)N(C[C@@H]1COCCO1)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=XYIIXAYNGQSWLK-TZMCWYRMSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50484476   

TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50484476(CHEMBL1916325)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed