BDBM50485447 CHEMBL2059819

SMILES NC(=O)[C@@H](CCC(F)(F)F)N(C[C@H]1C[C@@H]1C#N)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=PPBDKFUHZARRNW-JTNHKYCSSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50485447   

TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50485447(CHEMBL2059819)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in human H4 cells expressing human APP swedish mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed