BDBM50490691 CHEMBL2336801

SMILES CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc2c(O)c(Cl)ccc2c1

InChI Key InChIKey=PAYFRWUVNIKPAR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50490691   

TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50490691(CHEMBL2336801)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant N-terminal His-tagged BRAF V600E mutant expressed in Sf9 cells using GST-tagged MEK1 and ATP as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50490691(CHEMBL2336801)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of BRAF V600E mutant in human WM266.4 cells assessed as inhibition of ERK phosphorylation after 6 hrs by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed