BDBM50490974 CHEMBL2376665::US20230270730, Compound ref-2
SMILES CNS(=O)(=O)Nc1cccc(Oc2cc(F)cc(Nc3ccc(I)cc3F)c2C(N)=O)c1
InChI Key InChIKey=XUMQXLFNDALQFY-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50490974
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha
US Patent
Chugai Seiyaku Kabushiki Kaisha
US Patent
Affinity DataIC50: 364nMAssay Description:The test compound, CRAF (Thermo Fisher Scientific Inc.), MEK1 (Thermo Fisher Scientific Inc.) and ERK2 (Carna Biosciences, Inc.) were mixed in ATP-co...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha
US Patent
Chugai Seiyaku Kabushiki Kaisha
US Patent
Affinity DataIC50: 22nMAssay Description:Inhibition of MEK1 (unknown origin) after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Chugai Seiyaku Kabushiki Kaisha
US Patent
Chugai Seiyaku Kabushiki Kaisha
US Patent
Affinity DataIC50: 12nMAssay Description:The test compound, BRAF (Eurofins Genomics KK.) and MEK1 (Thermo Fisher Scientific Inc.) were mixed in ATP-containing buffer and reacted for 90 minut...More data for this Ligand-Target Pair