BDBM50491628 CHEMBL2386352

SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(c(CC(O)=O)c2c1)C(F)(F)F

InChI Key InChIKey=KDIVDXIRWHFVLU-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50491628   

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50491628(CHEMBL2386352)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity to wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50491628(CHEMBL2386352)
Affinity DataIC50:  388nMAssay Description:Inhibition of wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrate incubated for 17 mins at 25 degC followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50491628(CHEMBL2386352)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of wild type ovine COX1 expressed in ram seminal vesicles using [1-14C]-arachidonic acid as substrate incubated for 17 mins at 25 degC fol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50491628(CHEMBL2386352)
Affinity DataIC50:  267nMAssay Description:Inhibition of wild type mouse COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrate incubated for 17 mins at 25 degC followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50491628(CHEMBL2386352)
Affinity DataIC50:  150nMAssay Description:Inhibition of COX2 in human HNSCC1483 cells using [1-14C]-arachidonic acid as substrate assessed as inhibition of substrate oxygenation preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed