BDBM50491733 CHEMBL2385554::US10865384, Compound IM-26

SMILES Cc1cccc(c1)-c1nc([nH]c1-c1ccncc1)-c1c(F)cccc1F

InChI Key InChIKey=QEXCGBIQJWBHDU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50491733   

TargetMitogen-activated protein kinase 14(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50: 4.30nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant GST-tagged p38alpha MAP kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50: 44nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50: 44nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50: 78nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
Agency For Science, Technology and Research

US Patent
LigandPNGBDBM50491733(CHEMBL2385554 | US10865384, Compound IM-26)
Affinity DataIC50: 78nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2021
Entry Details
US Patent