BDBM50493620 CHEMBL2436792

SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(OC(F)(F)F)cc2)c1F

InChI Key InChIKey=SJFJIQHFVSHARS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50493620   

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50493620(CHEMBL2436792)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of full length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50493620(CHEMBL2436792)
Affinity DataIC50: 86nMAssay Description:Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed