BDBM50493811 CHEMBL2443278

SMILES C(C[C@]1(CCOC2(CCCC2)C1)c1ccccn1)NCc1cccs1

InChI Key InChIKey=PJLIHYXPEOMIMJ-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50493811   

TargetMu-type opioid receptor(Human)
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataEC50:  251nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataEC50:  750nMAssay Description:Agonist activity at human delta opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataEC50:  900nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human Nav 1.5 tonic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cav 1.2 ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed