BDBM50494389 CHEMBL3086246

SMILES CC(C)(C)OC(=O)N(C[C@@H](O)c1cccc(NC(=O)[C@H](NC(=O)OCc2ccccc2)c2ccccc2)c1)Cc1ccccc1

InChI Key InChIKey=GNUADQAMBDJORV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50494389   

TargetBeta-secretase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50494389(CHEMBL3086246)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human recombinant BACE1 using [acetyl-C(W8044Eu)-EVNLDAEFK-QSY7] as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50494389(CHEMBL3086246)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APP NFEV and APP K612V mutant assessed as generation of EV40/EV42 by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50494389(CHEMBL3086246)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing APP NFEV and wild-type alpha cleavage site assessed as generation of EV40/EV42 by electrochemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed