BDBM50496951 CHEMBL3236461

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2)c1F

InChI Key InChIKey=JYVXDEQFHMIAOD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50496951   

TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496951(CHEMBL3236461)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496951(CHEMBL3236461)
Affinity DataIC50: 55nMAssay Description:Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496951(CHEMBL3236461)
Affinity DataIC50: 69nMAssay Description:Inhibition of BRAF V600E mutant in human A-375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50496951(CHEMBL3236461)
Affinity DataIC50: 88nMAssay Description:Inhibition of 6-His tagged BRAF V600E mutant (445 to 723 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed