BDBM50499238 CHEMBL3735263

SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC2CCN(C(=N)N)CC2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O

InChI Key InChIKey=OHKHDWZCCRSLRV-UHFFFAOYSA-N

Data  19 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50499238   

TargetPlasma kallikrein(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKd:  3nMAssay Description:Binding affinity to human plasma kallikrein by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human wild-type plasma kallikrein catalytic domain after 15 mins using H-D-Pro-Phe-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  14nMAssay Description:Inhibition of human plasma kallikrein for 15 mins using H-D-Pro-Phe-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  32nMAssay Description:Inhibition of human plasma kallikrein catalytic domain E217A mutant after 15 mins using H-D-Pro-Phe-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasma kallikrein(Mouse)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  50nMAssay Description:Inhibition of mouse plasma kallikrein for 15 mins using H-D-Pro-Phe-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  54nMAssay Description:Inhibition of human plasma kallikrein catalytic domain G99Y mutant after 15 mins using H-D-Pro-Phe-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  166nMAssay Description:Inhibition of human plasma kallikrein catalytic domain E217R mutant after 15 mins using H-D-Pro-Phe-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetKallikrein-1(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  833nMAssay Description:Inhibition of human KLK1 after 15 mins using Val-Leu-Lys-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasminogen(Mouse)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  3.67E+3nMAssay Description:Inhibition of mouse plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  6.63E+3nMAssay Description:Inhibition of human coagulation factor 11a after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  9.80E+3nMAssay Description:Inhibition of human plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi:  7.34E+4nMAssay Description:Inhibition of bovine beta-trypsin after 15 mins using Bz-Ile-Glu(g-OR)-Gly-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Mouse)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of mouse uPA for 15 mins using pyro-Glu-Gly-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of human activated protein C after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of human thrombin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProthrombin(Mouse)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of mouse thrombin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of human matriptase after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of human uPA for 15 mins using pyro-Glu-Gly-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Mouse)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of mouse tPA after 15 mins using Z-D-Arg-Gly-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Aarhus University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50499238BDBM50499238(CHEMBL3735263)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of human tPAn after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed