BDBM50499446 CHEMBL3740669

SMILES [H][C@@]12CN(CC3CCN(CC3)C(=O)OC)C[C@]1([H])[C@H]2CNC(=O)c1nc(C(C)C)n2ccccc12

InChI Key InChIKey=BSCSBDJBDPHGLX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50499446   

Target5-hydroxytryptamine receptor 4(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50499446(CHEMBL3740669)
Affinity DataEC50:  8.70nMAssay Description:Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50499446(CHEMBL3740669)
Affinity DataIC50: 5.43E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 2 mins by LC-MS/MS analysis in presence of NADPH regeneration syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50499446(CHEMBL3740669)
Affinity DataIC50: 8.85E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 12 mins by LC-MS/MS analysis in presence of NADPH regenerati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed