BDBM50503245 CHEMBL4462489

SMILES CC(C)N1C(=O)OCc2cnc(N[C@H](C)c3ccc(CN4CCN(CC4)C(=O)C=C)cc3)nc12

InChI Key InChIKey=AZWXCHCQFFUQCW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50503245   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503245(CHEMBL4462489)
Affinity DataIC50: 27nMAssay Description:Inhibition of N-terminal His-tagged IDH1 R132C mutant (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503245(CHEMBL4462489)
Affinity DataIC50: 29nMAssay Description:Inhibition of N-terminal His-tagged IDH1 R132H mutant (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503245(CHEMBL4462489)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of N-terminal His-tagged IDH2 R172K mutant (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503245(CHEMBL4462489)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of wild type N-terminal His-tagged IDH1 (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503245(CHEMBL4462489)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of wild type N-terminal His-tagged IDH2 (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503245(CHEMBL4462489)
Affinity DataIC50: 4.18E+4nMAssay Description:Inhibition of N-terminal His-tagged IDH2 R140Q mutant (unknown origin) expressed in Escherichia coli using alpha-KG as substrate assessed as decrease...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed