BDBM50503255 CHEMBL4536525

SMILES Cc1ccc(Cl)cc1NC(=O)Nc1cc(NC(=O)c2ccccc2)ccc1N1CCCC1

InChI Key InChIKey=JOZBIBZIRIKWFL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50503255   

TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503255(CHEMBL4536525)
Affinity DataIC50: 41nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) by NADPH depletion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50503255(CHEMBL4536525)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin) by NADPH depletion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed