BDBM50503445 CHEMBL4445544::US11274074, Example 1 [Chemical Formula 5]

SMILES Cc1cc(Cl)ccc1OCC(=O)N\N=C\c1ccccc1OC(F)(F)F

InChI Key InChIKey=ZHUMOPHHIOSSLV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50503445   

TargetAnoctamin-1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50: 21nMAssay Description:Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAnoctamin-1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50: 21nMAssay Description:The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

TargetAnoctamin-1(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50503445(CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed