BDBM50503495 CHEMBL4514358::US10626103, Example 94

SMILES CN(C)[C@H]1CCN(C1)C(=O)c1nc(-c2ccc(C#N)c(F)c2)n(c1C)-c1ccc2nn(C)cc2c1

InChI Key InChIKey=JGLUMEJYVBYXSD-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50503495   

TargetLysine-specific histone demethylase 1A(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50503495(CHEMBL4514358 | US10626103, Example 94)
Affinity DataIC50: 7nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50503495(CHEMBL4514358 | US10626103, Example 94)
Affinity DataEC50:  43nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of CD11b expression after 4 days by LIVE/DEAD violet staining based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM50503495(CHEMBL4514358 | US10626103, Example 94)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent