BDBM50505302 CHEMBL4527563::US11534443, Example 44

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1cc(OC2CCOCC2)c2ncnc(C)c2c1

InChI Key InChIKey=HLTLYKPFSSMNIF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50505302   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged full-length p110delta/human p85alpha expressed in Sf9 insect cells using PIP2 as substrate by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of PI3K delta (unknown origin) using PIP2 as substrate incubated in dark at room temperature for 1 hr in presence of ATP by ADP-Glo lumine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged full-length p110beta/human p85alpha expressed in Sf9 insect cells using PIP2 as substrate by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of PI3K beta (unknown origin) using PIP2 as substrate incubated in dark at room temperature for 1 hr in presence of ATP by ADP-Glo lumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged full-length p110alpha/human p85alpha expressed in Sf9 insect cells using PIP2 as substrate by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PI3K alpha (unknown origin) using PIP2 as substrate incubated in dark at room temperature for 1 hr in presence of ATP by ADP-Glo lumine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 0.650nMAssay Description:The Kinase-Glo Kinase Assay Kit was purchased from Promega. All assays were performed at room temperature using white OptiPlate -384 well plate. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full-length p120gamma expressed in Sf9 insect cells using PIP2 as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PI3K gamma (unknown origin) using PIP2 as substrate incubated in dark at room temperature for 1 hr in presence of ATP by ADP-Glo lumine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed