BDBM50505828 CHEMBL4527023
SMILES Oc1ccc(F)cc1-c1ccnc2c(O)c(NC(=O)CCN3CCOCC3)ccc12
InChI Key InChIKey=HLISXOVPVKOKNV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50505828
Affinity DataIC50: 600nMAssay Description:Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with EcadPro-RFP reporter assessed as reversion of epithelial-mesenchymal tra...More data for this Ligand-Target Pair
Affinity DataEC50: 1.90E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with VimPro-GFP reporter assessed as reversion of epithelial-mesenchymal tran...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of topoisomerase 2alpha dependent TCF transcription in human SW620 organoids transduced with TOPflash luminescent reporter after 72 hrs by...More data for this Ligand-Target Pair