BDBM50507259 CHEMBL4461622

SMILES ONC(=O)CCCCCN1C(=O)c2cccc3c(Nc4cccc(F)c4)ccc(C1=O)c23

InChI Key InChIKey=BBHHBNFCYBGQHQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50507259   

TargetHistone deacetylase 6(Human)
Deakin University

Curated by ChEMBL
LigandPNGBDBM50507259(CHEMBL4461622)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using RHKK-Ac as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Deakin University

Curated by ChEMBL
LigandPNGBDBM50507259(CHEMBL4461622)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant C-terminal His-tagged human HDAC11 (1 to 347 residues) expressed in Baculovirus infected insect cells using RHKK-Ac as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507259(CHEMBL4461622)
Affinity DataIC50: 550nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Deakin University

Curated by ChEMBL
LigandPNGBDBM50507259(CHEMBL4461622)
Affinity DataIC50: 3.06E+3nMAssay Description:Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Deakin University

Curated by ChEMBL
LigandPNGBDBM50507259(CHEMBL4461622)
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of recombinant C-terminal His-tagged human HDAC8 (1 to 377 residues) expressed in Baculovirus infected insect cells using RHK-K(Ac)-AMC as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed