BDBM50510261 CHEMBL4590082

SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1cc2CN(CCc2o1)C(=O)CC#N

InChI Key InChIKey=QOEGOFYHVBZIQG-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50510261   

TargetTyrosine-protein kinase JAK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JAK2 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 3nMAssay Description:Inhibition of Tyk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of JAK1 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of JAK3 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetLysine--tRNA ligase(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 140nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 146nMAssay Description:Inhibition of JAK2 in human TF-1 cells assessed as reduction in GM-CSF-induced cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 543nMAssay Description:Inhibition of JAK3 in human HT-2 cells assessed as reduction in IL-2-induced cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of JAK2 V617F mutant in human HEL cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510261(CHEMBL4590082)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed