BDBM50510288 CHEMBL4445556

SMILES NC[C@H](Oc1noc2ccc(cc12)-c1ccccc1Cl)c1ccccc1

InChI Key InChIKey=HHSLFPVGKCXEOG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50510288   

TargetDNA gyrase A/A/B/B tetramer(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510288(CHEMBL4445556)
Affinity DataIC50: 160nMAssay Description:Inhibition of Escherichia coli his-tagged DNA gyrase supercoiling activity using pBR322 DNA in presence of ATP incubated for 1 hr by H19 dye based hi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510288(CHEMBL4445556)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human NaV1.5 expressed in HEK293 cells assessed as decrease in sodium current amplitude at -120 mV holding potential by Qpatch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510288(CHEMBL4445556)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human ERG by QPatch assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50510288(CHEMBL4445556)
Affinity DataIC50: 2.10E+5nMAssay Description:Inhibition of human DNA topoisomerase 2 alpha using interlinked kDNA as substrate after 30 mins by ethidium bromide staining-based agarose gel electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed