BDBM50510796 CHEMBL4462314

SMILES [H][C@@]12CCC(F)(F)[C@]1([H])[C@](C)(N=C(N)O2)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=VGNRLIUKCSHVAX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50510796   

TargetBeta-secretase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510796(CHEMBL4462314)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP695 assessed as reduction in amyloidbeta 40 level incubated for 18 to 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed