BDBM50511353 CHEMBL4518564::US11034698, Example 152

SMILES Cn1ccc2cc(NC(=O)c3cnn4cccnc34)c(cc2c1=O)N1CCOCC1

InChI Key InChIKey=ASEWBZJHLDHXLR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50511353   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50511353(CHEMBL4518564 | US11034698, Example 152)
Affinity DataKi:  210nMAssay Description:The IRAK4 reaction conditions were optimized using an IRAK1-derived peptide (sequence H-KKARFSRFAGSSPSQSSMVAR) to provide a linear reaction rate over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50511353(CHEMBL4518564 | US11034698, Example 152)
Affinity DataKi:  210nMAssay Description:Inhibition of recombinant full-length N-terminal His6-tagged human IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed