BDBM50511537 CHEMBL4470270
SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC(F)(F)F)c1cc(F)cc(F)c21
InChI Key InChIKey=ZBQDZIKGERQLAW-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50511537
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair