BDBM50511565 CHEMBL4539435
SMILES C[C@H]1CN(C[C@@H](C)N1)c1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1
InChI Key InChIKey=AFEVCFCEYWOQKD-CALCHBBNSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50511565
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Japanese Foundation For Cancer Research
Curated by ChEMBL
Japanese Foundation For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair