BDBM50512270 CHEMBL4476728

SMILES Cc1ccc(COc2ccc3cc(\C=C4/SC(=S)N(C(Cc5c[nH]c6ccccc56)C(O)=O)C4=O)ccc3c2)cc1

InChI Key InChIKey=MCMHPYLLTIIZMQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50512270   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512270(CHEMBL4476728)
Affinity DataIC50: 640nMAssay Description:Inhibition of human recombinant GST-tagged PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 2(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512270(CHEMBL4476728)
Affinity DataIC50: 830nMAssay Description:Inhibition of human recombinant GST-tagged CDC25B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512270(CHEMBL4476728)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human recombinant GST-tagged TCPTP (catalytic domain 41 to 1075 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512270(CHEMBL4476728)
Affinity DataIC50: 3.99E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512270(CHEMBL4476728)
Affinity DataIC50: 5.81E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP2 (catalytic domain 1116 to 2162 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed