BDBM50512931 CHEMBL4528928

SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cn(C)nc1C

InChI Key InChIKey=ICJANEWBKSXXPZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50512931   

LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: 59nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: 63nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in calcium ionophore-stimulated LTB4 production preincubated for 30 mins followed by ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: 63nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by high-throughput electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBile salt export pump(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50512931(CHEMBL4528928)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected Sf21 insect cell vesicles assessed as reduction in NBD-taurocholate uptake by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed