BDBM50514114 CHEMBL4528101

SMILES CC(C)n1nc(cc1C(=O)Nc1ccc([C@H]2[C@@H](O)CCCc3cncn23)c(c1)-c1ccccc1)C(F)F

InChI Key InChIKey=ANNKHJQLDMGQFM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514114   

TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514114BDBM50514114(CHEMBL4528101)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of CSN5 (unknown origin) using fluorescence-labeled CRL substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514114BDBM50514114(CHEMBL4528101)
Affinity DataIC50: 6nMAssay Description:Inhibition of CSN5 (unknown origin) preincubated for 1 hr followed by PT22-Nedd8-Cul4A addition and measured after 1 hr by fluorescence polarization ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed