BDBM50514766 CHEMBL4531684

SMILES [H][C@@]12CCC[C@]1([H])N([C@@H](C2)c1ncc([nH]1)-c1ccc-2c(c1)-c1ccc(cc-21)-c1cnc([nH]1)[C@@H]1C[C@]2([H])CCC[C@]2([H])N1C(=O)[C@@H](NC(=O)OC)[C@@H](C)OC)C(=O)[C@@H](NC(=O)OC)[C@@H](C)O

InChI Key InChIKey=JHHBUCQLFXPVGX-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50514766   

TargetNonstructural protein 5A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514766(CHEMBL4531684)
Affinity DataEC50:  0.00600nMAssay Description:Inhibition of NS5A in patient-derived HCV genotype 3a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514766(CHEMBL4531684)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A in HCV genotype 1b infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514766(CHEMBL4531684)
Affinity DataEC50:  0.0140nMAssay Description:Inhibition of NS5A in HCV genotype 1a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514766(CHEMBL4531684)
Affinity DataEC50:  0.188nMAssay Description:Inhibition of NS5A in HCV genotype 2a con infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514766(CHEMBL4531684)
Affinity DataEC50:  1.03nMAssay Description:Inhibition of NS5A in patient-derived HCV genotype 2a infected in HuH-Lcu-Neo cells assessed as reduction in viral replication incubated for 48 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed