BDBM50514904 CHEMBL4519945::US12110278, Compound 8

SMILES COC(=O)COc1ccc(NC(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)cc1

InChI Key InChIKey=YOPTXGDOMWBLDF-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514904   

TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50514904(CHEMBL4519945 | US12110278, Compound 8)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to wild type human C-terminal thrombin cleavage site-fused/ 6xHis-tagged JAK2 JH2 pseudokinase domain (536 to 812 residues) expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H](Human)
Yale University

US Patent
LigandPNGBDBM50514904(CHEMBL4519945 | US12110278, Compound 8)
Affinity DataKd:  1.90E+3nMAssay Description:In a flat black bottom 96 well plate (Corning), the buffer (20 mM Tris-HCl pH 8.0, 150 mM NaCl, 20% Glycerol, 0.5 mM TCEP, 0.01% Tween 20) is added&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2025
Entry Details
US Patent