BDBM50515263 CHEMBL4531109

SMILES O=C(\C=C1/Nc2ccccc2NC1=O)c1cccc2ccccc12

InChI Key InChIKey=ZMFVICCTJZQVDM-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50515263   

TargetEpithelial discoidin domain-containing receptor 1(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 160nMAssay Description:Inhibition of DDR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 160nMAssay Description:Inhibition of human DDR1 using KKKSPGEYVNIEFG as substrate after 40 mins by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant human full-length JNK3 using ATF2 as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 250nMAssay Description:Inhibition of human JNK3 after 40 mins by [gamma-33ATP] radiometric assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 250nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 370nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 370nMAssay Description:Inhibition of human EGFR L858R/T790M mutant GGMEDIYFEFMGGKKK as substrate measured after 40 mins in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant human EGFR T790M/L858R double mutant (696 to end residues) using GGMEDIYFEFMGGKKK as substrate measured after 40 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human EGFR L858R using poly[Glu:Tyr] (4:1) as substrate measured after 40 mins in presence of [gamma-33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human EGFR L858R mutant (696 to end residues) using poly (Glu, Tyr) 4:1 as substrate measured after 40 mins in presence of [gamma33P]AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human JNK1alpha1 after 40 mins by [gamma-33ATP] radiometric assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human JNK2alpha2 after 40 mins by [gamma-33ATP] radiometric assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human JNK2alpha2 using ATF2 as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human JNK1alpha1 using ATF2 as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50515263(CHEMBL4531109)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed