BDBM50518327 CHEMBL4448579

SMILES COCCN1CCN(CC1)c1ccc(OCc2ccccc2)c(c1)C(=O)Nc1ccnnc1

InChI Key InChIKey=AJKHEQUQNWCJNL-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50518327   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50518327(CHEMBL4448579)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant 6His-Tev-tagged LRRK2 (1326 to 2527) (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotin-RLGRD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50518327(CHEMBL4448579)
Affinity DataIC50: 251nMAssay Description:Inhibition of parkinson's patient-derived LRRK2 G2019S mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50518327(CHEMBL4448579)
Affinity DataIC50: 398nMAssay Description:Inhibition of human lymphoblastoid cell-derived LRRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50518327(CHEMBL4448579)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of human ERG by IonWork assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50518327(CHEMBL4448579)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4 using atorvastatin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50518327(CHEMBL4448579)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Gsk Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50518327(CHEMBL4448579)
Affinity DataEC50: <5.01E+4nMAssay Description:Activation of human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed