BDBM50519614 CHEMBL4439276

SMILES CN1CCN(CCOc2ccc(-c3c(sc4ncnc(O[C@H](Cc5ccccc5OCc5ccnn5CC(F)(F)F)C(O)=O)c34)-c3ccc(F)o3)c(C)c2Cl)CC1

InChI Key InChIKey=ZFBHXVOCZBPADE-SSEXGKCCSA-N

Data  5 KI  1 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50519614   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKi:  0.190nMAssay Description:Inhibition of MCl-1 (unknown origin)More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKi: <1.20nMAssay Description:Displacement of fluorescein labelled Puma-BH3 peptide from C-terminal MBP-fused human Mcl-1 (173 to 321 residues) expressed in Escherichia coli BL21(...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKi: <1.20nMAssay Description:Binding affinity to C-terminal MBP-fused human MCL1 (173 to 321 residues) expressed in Escherichia coli BL21(DE3)pLysS incubated for 2 hrs by fluores...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human Bcl-xL assessed as inhibition constant incubated for 2 hrs in presence of fluorescein-PUMA peptide by fluorescence polariza...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human Bcl-2 assessed as inhibition constant incubated for 2 hrs in presence of fluorescein-PUMA peptide by fluorescence polarizat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataIC50: <1.00E+6nMAssay Description:Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50519614(CHEMBL4439276)
Affinity DataKd:  0.190nMAssay Description:Binding affinity to C-terminal human Mcl-1-MBP fusion protein expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by surface p...More data for this Ligand-Target Pair