BindingDB BDBM50519662 CHEMBL4438748

BDBM50519662 CHEMBL4438748

SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1

InChI Key InChIKey=WVGDUQVQWLHVEA-UHFFFAOYSA-N

Data 363 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 363 hits for monomerid = 50519662

Rho-associated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
6/24/2023
Entry Details
PubMed

Rho-associated protein kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 3nMAssay Description:Inhibition of recombinant human ROCK2 (11 to 552 residues) using KEAKEKRQEQIAKR as substrate incubated for 40 mins in presence of [gamma-33P]ATP and ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Rho-associated protein kinase 1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 14nMAssay Description:Inhibition of recombinant human ROCK1 (17 to 535 residues) using KEAKEKRQEQIAKR as substrate incubated for 40 mins in presence of [gamma-33P]ATP and ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Rho-associated protein kinase 1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 15nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
6/24/2023
Entry Details
PubMed

LIM domain kinase 2(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 46nMAssay Description:Inhibition of human LIMK2 in presence of 10 uM of ATP by radiometric analysisMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

cGMP-dependent protein kinase 1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 517nMAssay Description:Inhibition of recombinant full length human PKG1alpha using RRRLSFAEPG as substrate incubated for 40 mins in presence of [gamma-33P]ATP and 10 uM ATP...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

cGMP-dependent protein kinase 1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 660nMAssay Description:Inhibition of recombinant full length human PKG1beta using RRRLSFAEPG as substrate incubated for 40 mins in presence of [gamma-33P]ATP by radiometric...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Aurora kinase B(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.24E+3nMAssay Description:Inhibition of recombinant full length human AURORA-B using AKRRRLSSLRA as substrate incubated for 40 mins in presence of [gamma-33P]ATP and 10 uM ATP...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length PI3K p110alpha/p85alpha E545K mutant using phosphatidylinositol 4,5-bisphosphate as substrate incubated f...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of human PI3KC2More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Tyrosine-protein kinase ZAP-70(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full length human ZAP70 using poly(Glu, Tyr) 4:1 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiome...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length PI3K p110beta/p85alpha using phosphatidylinositol-4, 5-bisphosphate as substrate incubated for 40 mins in...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Tyrosine-protein kinase Yes(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full-length human Yes using poly(Glu, Tyr) 4:1 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometr...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Mitogen-activated protein kinase kinase kinase 20(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full-length human ZAK using MBP as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintillatio...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Wee1-like protein kinase 2(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full length human WEE1b using LSNLYHQGKFLQTFCGSPLYRRR as substrate incubated for 120 mins in presence of [gamma33P]ATP by r...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase WNK1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human WNK1 (1 to 491 residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma33P]ATP b...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase ULK3(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length ULK3 using casein as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase VRK1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of human VRK1 in presence of 10 uM ATP by radiometric analysisMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Dual specificity protein kinase TTK(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full-length human TTK S389A mutant using MBP as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Non-receptor tyrosine-protein kinase TYK2(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 mins in presence of [gamma33P]ATP by rad...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Testis-specific serine/threonine-protein kinase 2(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full-length human TSSK2 using KKKVSRSGLYRSP as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric ...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Tau-tubulin kinase 2(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human TTBK2 (1 to331 residues) using casein as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase SIK1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SIK (1 to 281 residues) using AMARAASAAALARas substrate incubated for 40 mins in presence of [gamma33P]ATP by radiome...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Inhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full length human IKKalpha using peptide substrate after 40 mins by [gamma-33ATP]by radiometric scintillation counting anal...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase/endoribonuclease IRE1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant IRE1 (465 to end residues) using myelin basic protein as substrate after 40 mins by [gamma-33ATP] by radiometric scin...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Tyrosine-protein kinase HCK(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant activated HCK (230 to 497 residues) using GGMEDIYFEFMGG as substrate after 40 mins by [gamma-33ATP] radiometric assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Homeodomain-interacting protein kinase 4(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of human recombinant full length HIPK4 using RRRFRPASPLRGP as substrate after 40 mins by [gamma-33ATP] radiometric assayMore data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

eIF-2-alpha kinase GCN2(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full length human GCN2 E556G mutant using RSRSRSRSRSRSR as substrate after 40 mins in presence of [gamma-33ATP] by radiomet...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Rhodopsin kinase GRK7(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full length human GRK7 using casein as substrate after 40 mins in presence of [gamma-33ATP] by radiometric scintillation co...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Tyrosine-protein kinase Fgr(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human FGR (2 to end residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33ATP] by radiometr...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Macrophage colony-stimulating factor 1 receptor(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human FMS (538 to end residues) using KKKSPGEYVNIEF as substrate after 40 mins in presence of [gamma-33ATP] by radiometric ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Receptor tyrosine-protein kinase erbB-4(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human ERBB4 (706 to 991 residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33ATP] by radio...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Tyrosine-protein kinase Fes/Fps(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human FES (2 to end residues) using poly(Glu, Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33ATP] by radiometr...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

DNA-dependent protein kinase catalytic subunit(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full length human DNA-PK using GST-cMyc-p53 as substrate incubated for 40 mins by fluorescence assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Ephrin type-A receptor 8(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human EPhA8 (615 to 911 residues) at 1 uM using KTFCGTPEYLAPE as substrate incubated for 40 mins in presence of [gamma-33PA...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Testis-specific serine/threonine-protein kinase 3(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full-length human TSSK3 using AMARAASAAALAR as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric ...More data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase WNK3(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human WNK3 (1 to 434 residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma33P]ATP b...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

SRSF protein kinase 1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SRPK1 (2 to end residues) using RSRSRSRSRSRSRSR as substrate incubated for 40 mins in presence of [gamma33P]ATP by ra...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

TRAF2 and NCK-interacting protein kinase(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of human TNIK (1 to 367 residues) using RLGRDKYKTLRQI as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scint...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Platelet-derived growth factor receptor alpha(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of human PDGFRalpha (550 to end residues) using poly(Glu, Tyr) 4:1 as substrate measured after 40 mins in presence of [gamma33P]ATP by rad...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

3-phosphoinositide-dependent protein kinase 1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PDK1 (52 to end residues) using KTFCGTPEYLAPE as substrate incubated for 40 mins in presence of [gamma33P]ATP by radi...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

NUAK family SNF1-like kinase 2(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full length NUAK2 using KKKVSRSGLYRSP as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase PAK 5(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PAK5 (425 to end residues) using RRRLSFAEPG as substrate measured after 40 mins in presence of [gamma33P]ATP by radio...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase Nek1(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human NEK1 (1 to 505 residues) using RLGRDKYKTLRQI as substrate measured after 40 mins in presence of [gamma33P]ATP by radi...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase Nek6(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human NEK6 (2 to end residues) using FLAKSFGSPNRAYKK as substrate measured after 40 mins in presence of [gamma33P]ATP by ra...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

SRSF protein kinase 3(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant full-length human MSSK1 using ERMRPRKRQGSVRRRV as substrate measured after 40 mins in presence of [gamma33P]ATP by radiomet...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Muscle, skeletal receptor tyrosine-protein kinase(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MUSK (530 to end residues) using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P]AT...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Myosin light chain kinase, smooth muscle(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MLCK (1425 to 1771 residues) using calmodulin as substrate incubated for 40 mins in presence of [gamma-33ATP by radio...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Serine/threonine-protein kinase MRCK beta(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MRCKbeta (1 to 473 residues) using KKRNRTLTV as substrate incubated for 40 mins in presence of [gamma-33ATP by radiom...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Hepatocyte growth factor receptor(Human)
TBA

Curated by ChEMBL

BDBM50519662(CHEMBL4438748)

IC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MET A1209G/V1290L double mutant (974 to end residues) using KKKGQEEEYVFIE as substrate incubated for 40 mins in prese...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
2/23/2021
Entry Details Article
PubMed

Displayed 1 to 50 (of 363 total ) | Next | Last >>

Filter my 363 hits

Targets 319▿
- Hepatocyte growth factor receptor 7
- Tyrosine-protein kinase ABL1 6
- Mast/stem cell growth factor receptor Kit 5
- Epidermal growth factor receptor 5
- Serine/threonine-protein kinase Chk2 3
- Proto-oncogene tyrosine-protein kinase receptor Ret 3
- Proto-oncogene tyrosine-protein kinase Src 3
- Platelet-derived growth factor receptor alpha 3
- Receptor-type tyrosine-protein kinase FLT3 2
- Tyrosine-protein kinase Lck 2
- Tyrosine-protein kinase BTK 2
- Protein kinase C beta type 2
- Insulin-like growth factor 1 receptor 2
- Macrophage colony-stimulating factor 1 receptor 2
- Rho-associated protein kinase 2 2
- cGMP-dependent protein kinase 1 2
- Rho-associated protein kinase 1 2
- Mitogen-activated protein kinase 14 2
- Insulin receptor 2
- Serine/threonine-protein kinase B-raf 2
- Casein kinase II subunit alpha 2
- Tyrosine-protein kinase HCK 2
- Fibroblast growth factor receptor 1 2
- Cyclin-dependent kinase 5 activator 1 2
- Fibroblast growth factor receptor 2 2
- Serine/threonine-protein kinase haspin 1
- Cyclin-dependent kinase 13/Cyclin-K 1
- Casein kinase II subunit alpha 3 1
- Tyrosine-protein kinase JAK1 1
- Rhodopsin kinase GRK1 1
- LIM domain kinase 1 1
- LIM domain kinase 2 1
- ALK tyrosine kinase receptor 1
- NUAK family SNF1-like kinase 2 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Glycogen synthase kinase-3 beta 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- Protein kinase C iota type 1
- NUAK family SNF1-like kinase 1 1
- Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 1
- Transient receptor potential cation channel subfamily M member 7 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1
- Serine/threonine-protein kinase PAK 3 1
- Dual specificity mitogen-activated protein kinase kinase 2 1
- Serine/threonine-protein kinase PAK 4 1
- Serine/threonine-protein kinase tousled-like 2 1
- Serine/threonine-protein kinase PAK 5 1
- Serine/threonine-protein kinase PAK 6 1
- Serine/threonine-protein kinase tousled-like 1 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Tyrosine-protein kinase ZAP-70 1
- Leucine-rich repeat serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk1 1
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 1
- Casein kinase I isoform gamma-3 1
- Casein kinase I isoform gamma-2 1
- Serine/threonine-protein kinase Sgk3 1
- Casein kinase I isoform gamma-1 1
- Ephrin type-A receptor 1 1
- Ephrin type-A receptor 3 1
- Ephrin type-A receptor 2 1
- Ephrin type-A receptor 5 1
- Ephrin type-A receptor 4 1
- Ephrin type-A receptor 7 1
- Hexokinase-4 1
- FKBP12A/mTOR 1
- Tyrosine-protein kinase receptor UFO 1
- DNA-dependent protein kinase catalytic subunit 1
- Activin receptor type-1 1
- Myosin light chain kinase 2, skeletal/cardiac muscle 1
- Cell division cycle 7-related protein kinase/G2/mitotic-specific cyclin-B1 1
- Wee1-like protein kinase 1
- Cyclin-Y 1
- Serine/threonine-protein kinase/endoribonuclease IRE1 1
- Serine/threonine-protein kinase MAK 1
- Tyrosine-protein kinase Lyn 1
- Focal adhesion kinase 1 1
- Tyrosine-protein kinase TXK 1
- Rhodopsin kinase GRK7 1
- Ephrin type-A receptor 8 1
- Death-associated protein kinase 2 1
- Death-associated protein kinase 1 1
- TGF-beta receptor type-1 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- TGF-beta receptor type-2 1
- Serine/threonine-protein kinase D1 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Death-associated protein kinase 3 1
- Serine/threonine-protein kinase pim-3 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase pim-2 1
- Serine/threonine-protein kinase 35 1
- Testis-specific serine/threonine-protein kinase 1 1
- Protein kinase C epsilon type 1
- Testis-specific serine/threonine-protein kinase 2 1
- Bone morphogenetic protein receptor type-2 1
- Cyclin-dependent kinase 18 1
- Protein-tyrosine kinase 6 1
- Cyclin-dependent kinase 12 1
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 1
- Testis-specific serine/threonine-protein kinase 3 1
- Leukocyte tyrosine kinase receptor 1
- Testis-specific serine/threonine-protein kinase 4 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Tyrosine-protein kinase ABL2 1
- Serine/threonine-protein kinase A-Raf 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- cGMP-dependent protein kinase 2 1
- Serine/threonine-protein kinase ULK1 1
- Serine/threonine-protein kinase SIK2 1
- Tyrosine-protein kinase Fes/Fps 1
- Serine/threonine-protein kinase SIK1 1
- Serine/threonine-protein kinase SIK3 1
- Serine/threonine-protein kinase ULK2 1
- Serine/threonine-protein kinase ULK3 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- Discoidin domain-containing receptor 2 1
- Serine/threonine-protein kinase 4 1
- SRSF protein kinase 3 1
- SRSF protein kinase 2 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Mitogen-activated protein kinase 8 1
- Tyrosine-protein kinase SYK 1
- Serine/threonine-protein kinase TBK1 1
- Tribbles homolog 2 1
- Tau-tubulin kinase 1 1
- Serine/threonine-protein kinase 32B 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Serine/threonine-protein kinase 32A 1
- Tau-tubulin kinase 2 1
- Serine/threonine-protein kinase 32C 1
- Vascular endothelial growth factor receptor 2 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Serine/threonine-protein kinase PLK2 1
- Insulin receptor-related protein 1
- Transcription initiation factor TFIID subunit 1-like 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase NIM1 1
- Serine/threonine-protein kinase PLK3 1
- Tyrosine-protein kinase receptor TYRO3 1
- Wee1-like protein kinase 2 1
- Serine/threonine-protein kinase BRSK1 1
- Protein kinase C gamma type 1
- Serine/threonine-protein kinase BRSK2 1
- Protein kinase C zeta type 1
- Eukaryotic elongation factor 2 kinase 1
- Serine/threonine-protein kinase Chk1 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- SRSF protein kinase 1 1
- Tyrosine-protein kinase Yes 1
- Serine/threonine-protein kinase WNK1 1
- Serine/threonine-protein kinase MRCK beta 1
- Serine/threonine-protein kinase WNK3 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- Serine/threonine-protein kinase STK11 1
- Serine/threonine-protein kinase WNK2 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
- Receptor tyrosine-protein kinase erbB-4 1
- Receptor tyrosine-protein kinase erbB-2 1
- Tyrosine-protein kinase FRK 1
- Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 1
- Serine/threonine-protein kinase Nek9 1
- Serine/threonine-protein kinase Nek7 1
- Glycogen synthase kinase-3 alpha 1
- Serine/threonine-protein kinase Nek6 1
- Serine-protein kinase ATM 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek3 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase receptor R3 1
- Serine/threonine-protein kinase Nek1 1
- Macrophage-stimulating protein receptor 1
- Cyclin-dependent kinase-like 4 1
- Cyclin-dependent kinase-like 3 1
- Cyclin-dependent kinase-like 2 1
- Cyclin-dependent kinase-like 1 1
- MAP/microtubule affinity-regulating kinase 3 1
- Homeodomain-interacting protein kinase 4 1
- Homeodomain-interacting protein kinase 3 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase 10 1
- MAP/microtubule affinity-regulating kinase 4 1
- Serine/threonine-protein kinase 38-like 1
- Dual specificity protein kinase TTK 1
- Myosin-IIIb 1
- Serine/threonine-protein kinase Nek11 1
- Cyclin-A1/Cyclin-dependent kinase 2 1
- Eukaryotic translation initiation factor 2-alpha kinase 1 1
- Serine/threonine-protein kinase mTOR 1
- Eukaryotic translation initiation factor 2-alpha kinase 3 1
- Tyrosine-protein kinase ITK/TSK 1
- Myotonin-protein kinase 1
- Bone morphogenetic protein receptor type-1B 1
- Tyrosine-protein kinase Blk 1
- Receptor-interacting serine/threonine-protein kinase 1 1
- Serine/threonine-protein kinase 16 1
- Receptor-interacting serine/threonine-protein kinase 2 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Serine/threonine-protein kinase NLK 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Casein kinase I isoform delta 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Serine/threonine-protein kinase 26 1
- Serine/threonine-protein kinase 24 1
- Serine/threonine-protein kinase 25 1
- Ephrin type-B receptor 3 1
- Serine/threonine-protein kinase 33 1
- Ephrin type-B receptor 4 1
- Ephrin type-B receptor 1 1
- Serine/threonine-protein kinase SBK1 1
- Activated CDC42 kinase 1 1
- MAP kinase-activated protein kinase 3 1
- Platelet-derived growth factor receptor beta 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
- Tyrosine-protein kinase Fer 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- PAS domain-containing serine/threonine-protein kinase 1
- Beta-adrenergic receptor kinase 2 1
- Beta-adrenergic receptor kinase 1 1
- MAPK/MAK/MRK overlapping kinase 1
- Serine/threonine-protein kinase TAO1 1
- Calcium/calmodulin-dependent protein kinase kinase 1 1
- Serine/threonine-protein kinase DCLK2 1
- Serine/threonine-protein kinase TAO3 1
- Serine/threonine-protein kinase PRP4 homolog 1
- Calcium/calmodulin-dependent protein kinase kinase 2 1
- Serine/threonine-protein kinase TAO2 1
- Serine/threonine-protein kinase DCLK3 1
- Interferon-induced, double-stranded RNA-activated protein kinase 1
- Angiopoietin-1 receptor 1
- Mitogen-activated protein kinase kinase kinase kinase 3 1
- Mitogen-activated protein kinase kinase kinase kinase 1 1
- Serine/threonine-protein kinase MRCK alpha 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase kinase kinase kinase 5 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 1
- Activin receptor type-1B 1
- Interleukin-1 receptor-associated kinase 4 1
- Mitogen-activated protein kinase kinase kinase 9 1
- Serine/threonine-protein kinase VRK1 1
- Serine/threonine-protein kinase VRK2 1
- RAC-gamma serine/threonine-protein kinase 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Mitogen-activated protein kinase kinase kinase 2 1
- Mitogen-activated protein kinase kinase kinase 3 1
- Serine/threonine-protein kinase ICK 1
- Actin-related protein 2 1
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 1
- Myosin light chain kinase, smooth muscle 1
- BDNF/NT-3 growth factors receptor 1
- Serine/threonine-protein kinase 17A 1
- Serine/threonine-protein kinase 17B 1
- Dual specificity protein kinase CLK1 1
- CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 1
- Protein kinase C delta type 1
- NT-3 growth factor receptor 1
- G protein-coupled receptor kinase 5 1
- Dual specificity protein kinase CLK4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- G protein-coupled receptor kinase 6 1
- Protein-tyrosine kinase 2-beta 1
- Serine/threonine-protein kinase N2 1
- cAMP-dependent protein kinase catalytic subunit beta 1
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-2 1
- Ribosomal protein S6 kinase alpha-3 1
- Calcium/calmodulin-dependent protein kinase type 1B 1
- Ribosomal protein S6 kinase alpha-1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Calcium/calmodulin-dependent protein kinase type 1D 1
- STE20-like serine/threonine-protein kinase 1
- Calcium/calmodulin-dependent protein kinase type 1G 1
- Fibroblast growth factor receptor 4 1
- Tyrosine-protein kinase Fgr 1
- Aurora kinase B 1
- Mitogen-activated protein kinase kinase kinase 20 1
- Fibroblast growth factor receptor 3 1
- Aurora kinase C 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase 12 1
- Mitogen-activated protein kinase 11 1
- RAC-beta serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 10 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Ribosomal protein S6 kinase alpha-6 1
- Protein kinase C alpha type 1
- eIF-2-alpha kinase GCN2 1
- Ribosomal protein S6 kinase alpha-4 1
- Maternal embryonic leucine zipper kinase 1
- Ribosomal protein S6 kinase alpha-5 1
- Serine/threonine-protein kinase MARK2 1
- TRAF2 and NCK-interacting protein kinase 1
- Mitogen-activated protein kinase kinase kinase 10 1
- ...
Publications 2▿
- J Med Chem 62: 10691-10710 (2019) 361
- J Med Chem 64: 1283-1345 (2021) 2
Institutions 2▿
- TBA 361
- Hefei University of Technology 2
Affinity: 3 to 1.0E+4 nM▿
- IC50 363
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1