BDBM50519881 CHEMBL4435145

SMILES Cc1cc2n(nc(-c3ccc(cc3)C(O)=O)c2s1)C(=O)c1c(Cl)cccc1Cl

InChI Key InChIKey=LDKVVDVRWBVBGM-UHFFFAOYSA-N

Data  6 IC50  2 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50519881   

TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataIC50:  300nMAssay Description:Competitive inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataIC50:  425nMAssay Description:Inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as inh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataIC50:  269nMAssay Description:Competitive inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataEC50:  620nMAssay Description:Partial agonist activity at RORgammat (unknown origin) assessed as increase in FITC-labeled SRC1B2 peptide recruitment by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataIC50:  180nMAssay Description:Displacement of Alexa647-labeled MRL-87 from human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPeroxisome proliferator-activated receptor gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataIC50:  1.47E+4nMAssay Description:Inverse agonist activity at His6-tagged PPARgamma LBD (unknown origin) assessed as inhibition of rosiglitazone-induced N-terminal biotinylated co-act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataEC50:  300nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment by HTRF as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Human)
Technische Universiteit Eindhoven

Curated by ChEMBL
LigandPNGBDBM50519881(CHEMBL4435145)
Affinity DataIC50:  547nMAssay Description:Competitive inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB