BDBM50520033 CHEMBL4461382

SMILES Nc1ncc(cn1)-c1nc(nc(n1)N1CCN(CC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCOCC1

InChI Key InChIKey=XEBAVJCPTDOUIT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50520033   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50520033(CHEMBL4461382)
Affinity DataIC50:  0.832nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of biotinylated NAD+ by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50520033(CHEMBL4461382)
Affinity DataIC50:  94nMAssay Description:Inhibition of PI3K-alpha (unknown origin) incubated for 40 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50520033(CHEMBL4461382)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50520033(CHEMBL4461382)
Affinity DataIC50:  91nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed