BDBM50521268 CHEMBL4457303

SMILES COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@H](C2CC2)[C@@](C)(F)C(O)=O)CC1

InChI Key InChIKey=OBSQOGHKCGMNEP-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50521268   

TargetFree fatty acid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521268(CHEMBL4457303)
Affinity DataEC50:  0.25nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521268(CHEMBL4457303)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity at rat GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521268(CHEMBL4457303)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at human GPR40 expressed in CHOK1 cells assessed as induction of Galphaq-mediated IP1 accumulation after 90 mins HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50521268(CHEMBL4457303)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at GPR40 in human islets assessed as induction of glucose-stimulated insulin secretion after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed