BDBM50521590 CHEMBL4532181

SMILES CN1CCCC1c1cn(Cc2ccc(cc2)C(=O)NO)c2ccccc12

InChI Key InChIKey=JTPYEZDXQILRLC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50521590   

TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50521590(CHEMBL4532181)
Affinity DataIC50: 5nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50521590(CHEMBL4532181)
Affinity DataIC50: 5nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50521590(CHEMBL4532181)
Affinity DataIC50: 126nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC6 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50521590(CHEMBL4532181)
Affinity DataIC50: 158nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residues) express...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50521590(CHEMBL4532181)
Affinity DataIC50: 316nMAssay Description:Inhibition of recombinant full-length C-terminal FLAG-fused/His-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50521590(CHEMBL4532181)
Affinity DataIC50: 398nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected insect cells measured after 40 mins by HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM50521590(CHEMBL4532181)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant full-length C-terminal His-tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells measured after 40 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed