BDBM50522632 CHEMBL4544029

SMILES COc1c(ccc2[nH]c(cc12)-c1nc2[C@@H](OCCn2n1)c1ccc(F)cc1C)C#N

InChI Key InChIKey=XYQDAYZDRBKPNR-FQEVSTJZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50522632   

TargetPresenilin-1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50522632(CHEMBL4544029)
Affinity DataIC50:  32nMAssay Description:Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed