BDBM50524282 CHEMBL4467033

SMILES COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1OC

InChI Key InChIKey=NYSAXBWLXKKMCP-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50524282   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524282(CHEMBL4467033)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524282(CHEMBL4467033)
Affinity DataIC50: <15nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50524282(CHEMBL4467033)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed