BDBM50525297 CHEMBL4567974

SMILES COc1cc(ccc1Nc1ccc(N2CCCC2)c(Oc2ccc(c(NC(=O)C=C)c2)C(F)(F)F)n1)N1CCN(C)CC1

InChI Key InChIKey=DAFUUYWXBRQLNF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50525297   

TargetDipeptidyl peptidase 1(Human)
National Institute of Biological Sciences (Nibs)

Curated by ChEMBL
LigandPNGBDBM50525297(CHEMBL4567974)
Affinity DataIC50: 4nMAssay Description:Inhibition of CatL-activated recombinant human C-terminal His10-tagged cathepsin C (25 to 463 residues) expressed in mouse myeloma cells using Gly-Ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
National Institute of Biological Sciences (Nibs)

Curated by ChEMBL
LigandPNGBDBM50525297(CHEMBL4567974)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of cathepsin C in human THP1 cells using H-Gly-Phe-AFC as substrate preincubated for 4 hrs followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
National Institute of Biological Sciences (Nibs)

Curated by ChEMBL
LigandPNGBDBM50525297(CHEMBL4567974)
Affinity DataIC50: 12nMAssay Description:Inhibition of cathepsin C in human U937 cells using H-Gly-Phe-AFC as substrate preincubated for 4 hrs followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed