BDBM50525810 CHEMBL4451680

SMILES [H][C@@]12CC[C@H](N3CCCC3)[C@@]1(C)CC[C@]1([H])c3ccc(OCCCN4CCCC4)cc3CC[C@@]21[H]

InChI Key InChIKey=PUEQNBHYHQKBQD-PNHLWVRCSA-N

Data  5 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50525810   

TargetHistamine H3 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataKi:  0.600nMAssay Description:Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from recombinant human histamine H3 receptor expressed in CHO-K1 cells assessed a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]methyl- N-alpha methylhistamine dihydrochloride from human recombinant H3 receptor expressed in CHOK1 cells measured after 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]methyl- N-alpha methylhistamine dihydrochloride from Sprague-Dawley rat cerebral cortex H3 receptor measured after 30 mins by sci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataKi:  2.40nMAssay Description:Displacement of N-alpha-[methyl-3H]-methylhistamine dihydrochloride from Sprague-Dawley rat brain membrane histamine H3 receptor assessed as inhibiti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]quinuclidinyl benzilate from Wistar rat cortex muscarinic acetylcholine receptor by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataEC50:  0.100nMAssay Description:Inverse agonist activity at recombinant human histamine H3 receptor expressed in CHO-K1 cells preincubated for 10 mins followed by [35S]GTPgammaS add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of imetit-stimulation ERK1/2 phosphorylation by E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chemical Works of Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50525810(CHEMBL4451680)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed