BDBM50526728 CHEMBL4463882::US10807974, Example 155::US10995088, Example 155::US11608330, Example 155

SMILES CCc1cc(cc(c1)S(=O)(=O)c1csc(CN)n1)-c1cnn(C)c1

InChI Key InChIKey=NLRNJSOGPZGEHF-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50526728   

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 176nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 320nMAssay Description:10. Incubate for 1 hr at room temp on a plate shaker, protected from light.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 320nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 1 hour at room temp on a plate shaker.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 425nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetLysyl oxidase homolog 3(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAmine oxidase [copper-containing] 3(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 7.43E+4nMAssay Description:Inhibition of recombinant human SSAO expressed in CHO cells using luminogenic MAO substrate measured after 1 hr by MAO-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD-amino-acid oxidase(Pig)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of porcine kidney DAO measured after 1 hrs by ROS-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50526728(CHEMBL4463882 | US10807974, Example 155 | US109950...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed