BDBM50527062 CHEMBL4456612

SMILES [H][C@@]12CN(CCN1c1c(OCC2)cnc2cc(c(Cl)cc12)-c1c(C)ccc2[nH]ncc12)C(=O)C=C

InChI Key InChIKey=SAJURXLPLIIFPC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50527062   

TargetGTPase KRas(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50527062(CHEMBL4456612)
Affinity DataIC50: 4.34E+3nMAssay Description:Inhibition of GDP bound biotinylated human C-terminal Avi/His6-tagged KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed