BDBM50527575 CHEMBL4542938::US11427593, Compound ZB-BD-164

SMILES CC(=O)Nc1ccc(Oc2ccc(F)cc2F)c(c1)-c1cc(C)c2n1cc[nH]c2=O

InChI Key InChIKey=BBACDMDIGLLXBW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50527575   

TargetBromodomain-containing protein 4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50527575(CHEMBL4542938 | US11427593, Compound ZB-BD-164)
Affinity DataIC50: 98nMAssay Description:Inhibition of SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K-Biotin binding to N-terminal His6-tagged BRD4 bromodomain 2 (344 to 455 residues) (un...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [49-170](Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM50527575(CHEMBL4542938 | US11427593, Compound ZB-BD-164)
Affinity DataIC50: 219nMAssay Description:AlphaScreen kit (Perkin Elmer) was used to detect effect of the compounds on binding of BRD4 bromodomain to acetylated histone H4 polypeptide. The br...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50527575(CHEMBL4542938 | US11427593, Compound ZB-BD-164)
Affinity DataIC50: 219nMAssay Description:Inhibition of SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K-Biotin binding to N-terminal His6-tagged BRD4 bromodomain 1 (49 to 170 residues) (unk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50527575(CHEMBL4542938 | US11427593, Compound ZB-BD-164)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MSGRGK(Ac)-GGK(Ac)GLGK(Ac)GGAKRHR-biotin binding to EP300 (1040 to 1160 residues) (unknown origin) expressed in Escherichia coli BL21 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed