BDBM50527607 CHEMBL4443548

SMILES CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(NCc3ccc(cn3)C(=O)NO)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=NNCNCNUUHFTRQN-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50527607   

TargetHistone deacetylase 6(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1125 residues) expressed in baculovirus infected insect cells using fluorogenic pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 26nMAssay Description:Inhibition of human PI3Kdelta assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 104nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in baculovirus infected insect cells using fluorogenic HD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 135nMAssay Description:Inhibition of human PI3Kgamma assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 204nMAssay Description:Inhibition of recombinant C-terminal His-fusion tagged and N-terminal Streptavidin2-tagged human HDAC8 (1 to 377 residues) expressed in insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 381nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged and C-terminal His-tagged HDAC4 expressed in baculovirus infected insect cells using fluorogeni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 392nMAssay Description:Inhibition of human PI3Kalpha assessed as reduction in PIP3 product complex formation by measuring displacement of biotin-labelled PIP3 from complex ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 439nMAssay Description:Inhibition of recombinant human C-terminal His-fusion tagged HDAC5 (657 to 1123 residues) expressed in baculovirus infected insect cells using fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of human recombinant N-terminal Streptavidin2-tagged HDAC11 (1 to 347 residues) expressed in baculovirus infected insect cells using fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 6.07E+3nMAssay Description:Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC10 (unknown origin) using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50527607(CHEMBL4443548)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant full length human C-terminal His-tagged HDAC3 (1 to 428 residues) expressed in baculovirus infected insect cells using fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed