BDBM50528019 CHEMBL4518951::US11634404, Compound 77

SMILES Clc1cccc2cc([nH]c12)C(=O)N1CCN(CCOc2cccnc2)CC1

InChI Key InChIKey=AIEYTUOHPYHFSW-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50528019   

TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50528019BDBM50528019(CHEMBL4518951 | US11634404, Compound 77)
Affinity DataEC50:  33nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandChemical structure of BindingDB Monomer ID 50528019BDBM50528019(CHEMBL4518951 | US11634404, Compound 77)
Affinity DataEC50:  33nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528019BDBM50528019(CHEMBL4518951 | US11634404, Compound 77)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528019BDBM50528019(CHEMBL4518951 | US11634404, Compound 77)
Affinity DataEC50:  617nMAssay Description:Agonist activity at human D2R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528019BDBM50528019(CHEMBL4518951 | US11634404, Compound 77)
Affinity DataEC50:  617nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50528019BDBM50528019(CHEMBL4518951 | US11634404, Compound 77)
Affinity DataEC50:  617nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent