BDBM50528034 CHEMBL4548345::US11634404, Compound 45

SMILES COc1ccc(OCCN2CCN(CC2)C(=O)c2cc3cccc(OC)c3[nH]2)cc1

InChI Key InChIKey=DHUSVAZDGLXZIV-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50528034   

TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528034(CHEMBL4548345 | US11634404, Compound 45)
Affinity DataEC50:  980nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528034(CHEMBL4548345 | US11634404, Compound 45)
Affinity DataEC50:  6.00E+3nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528034(CHEMBL4548345 | US11634404, Compound 45)
Affinity DataIC50: 1.00E+5nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528034(CHEMBL4548345 | US11634404, Compound 45)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human D2R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528034(CHEMBL4548345 | US11634404, Compound 45)
Affinity DataEC50:  980nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528034(CHEMBL4548345 | US11634404, Compound 45)
Affinity DataEC50:  6.00E+3nMAssay Description:Agonist activity at human D2R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed