BDBM50529077 CHEMBL4434876

SMILES Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(c1)-c1ccccc1

InChI Key InChIKey=DFEVQPHSPAIFED-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50529077   

LigandPNGBDBM50529077(CHEMBL4434876)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to human 5-HT1A receptor extracted from HEK293 cell membrane assessed as inhibition of [3H]-OH-DPAT binding to 5-HT1A by measuring i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetSodium-dependent serotonin transporter(Rat)
China State Institute of Pharmaceutical Industry

Curated by ChEMBL
LigandPNGBDBM50529077(CHEMBL4434876)
Affinity DataIC50: 14nMAssay Description:Inhibition of rat synaptosomes 5HT transporter assessed as reduction in [3H]serotonin reuptake incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529077(CHEMBL4434876)
Affinity DataKi:  27nMAssay Description:Binding affinity to human 5-HT7 receptor extracted from HEK293 cell membrane assessed as inhibition of [3H]LSD binding to 5-HT7 by measuring inhibiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50529077(CHEMBL4434876)
Affinity DataIC50: 251nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as reduction in 5-HT reuptake incubated for 30 mins by fluorescent dye uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50529077(CHEMBL4434876)
Affinity DataIC50: 650nMAssay Description:Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskoli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50529077(CHEMBL4434876)
Affinity DataEC50:  1.18E+3nMAssay Description:Agonist activity at human recombinant 5HT1A receptor (unknown origin) stably expressed in CHO-K1 incubated for 30 mins by [35S]GTPgammaS binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed